以卟啉衍生物为内核,采用可逆加成-断裂链转移(RAFT)聚合法合成了温度敏感性聚己内酯-聚N-异丙基丙烯酰胺.用FT-IR、1 H NMR、GPC、TEM、分子荧光、变温紫外、粒度分布等手段对聚合物进行了表征,并以紫杉醇为模型药物分子,进行了药物释放测试.结果表明,聚合物自组装后,形成了平均直径为100nm左右的胶束.这种内部亲脂外部亲水的核壳结构能够稳定地载药,在温度为15℃的DMF中,12h内释放了37％的药物,而在温度为38 C的DMF中,12h药物释放量为81.4％.这种两亲性大分子聚合材料对紫杉醇的释放具有温度敏感性,有望在抗癌药物的控制释放领域得到广泛应用.
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