将两种形态的AZ31B镁合金(条型内固定板和片状多孔板)植入实验动物(新西兰兔)体内, 并以钛合金板作为对照, 研究了镁合金在修复实验动物下颌骨表面不同形态骨缺损时的骨诱导作用. 结果表明, 镁合金条形内固定板植入90和180 d后, 周围有新骨生成, 新骨生成量高于对照组; 而片 状多孔板植入180 d后, 其下方出现不同程度的成骨和溶骨. AZ31B镁合金具有明显的诱导动物机体 新骨生成的能力; 但当镁合金降解产生的局部镁离子浓度过高时, 则会引起局部的溶骨反应
AZ31B magnesium alloy samples with two dimensions (stabilization splint and dictyo-plate) were implanted on the submaxilla surface of the New-Zealand rabbits, with comparison of Ti-6Al-4V titanium alloy as a control. Two kinds of bone coloboma were made on the submaxilla surface in order to model the different areas of bone defect. It was found from the experiments, after 3 and 6 months, that newly formed bone around the AZ31B magnesium alloy stabilization splint was much more than the control group. After 6 months, both newly formed bone and osteolysis were found on the surface of the dictyo-plate implants. It can be concluded that magnesium alloy implantation is beneficial to the new bone formation, but overdose of magnesium ions from biodegradation can also lead to the increase of osteoclast activity.
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