简要介绍了磁性靶向载药微球的特性及其作用原理,综述了制备磁性靶向载药微球的几种传统方法,并着重介绍了一种绿色有效的制备磁性靶向载药微球的方法——超临界CO2抗溶剂法.最后对超临界CO2抗溶剂法制备磁性靶向载药微球做了展望.
参考文献
| [1] | 邝银欢,蔡锦源.超临界流体技术在制备复合载药微粒领域中的应用[J].广东化工,2013(01):77-78. |
| [2] | Veiseh O;Gunn JW;Zhang M .Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging.[J].Advanced drug delivery reviews,2010(3):284-304. |
| [3] | 孙井辉;王红英 .纳米级磁性壳聚糖微球的靶向性研究[J].材料导报,2011,25(专辑17):177. |
| [4] | Renata A;Ernesto R .Composite polyrmer-Fe3O4 microcparticles for biomedical applications,produced by supercritical assisted atomization[J].Powder Technology,2012,218:102. |
| [5] | Kang Y;Wu J;Yin G;Huang Z;Yao Y;Liao X;Chen A;Pu X;Liao L .Preparation, characterization and in vitro cytotoxicity of indomethacin-loaded PLLA/PLGA microparticles using supercritical CO2 technique.[J].European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V,2008(1):85-97. |
| [6] | Furlan M;Kluge J .Preparation of biocompatible magnetitePLGA composite nanoparticles using supercritical fluid extraction of emulsions[J].Journal of Supercritical Fluids,2010,54(07):348. |
| [7] | Wang X Y;Zhou Z M .Synthesis of Fe3O4 poly(styreneglycidyl methacrylate) magnetic porous microspheres and application in the immobilization of Klebsiella sp.FD-3 to reduce Fe(Ⅲ)EDTA in a NOx scrubbing solution[J].Bioresoure Techn,2012,130:750. |
| [8] | 李亚瑜,毛晓颖,汪凌,甄卫军.Phen-Fe3O4/PLA-PEG-PLA微球的制备、表征及体外释放行为[J].材料导报,2012(08):85-88,101. |
| [9] | Saowaluk C;Nuttaporn P .Preparation of magnetic polymer microspheres with reactive epoxide functional groups for direct immobilization of antibody[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2012,414(20):66. |
| [10] | Amporn Sane;Jumras Limtrakul .Formation of retinyl palmitate-loaded poly(L-lactide) nanoparticles using rapid expansion of supercritical solutions into liquid solvents (RESOLV)[J].The Journal of Supercritical Fluids,2009(2):230-237. |
| [11] | Byrappa K;Ohara S;Adschiri T .Nanoparticles synthesis using supercritical fluid technology - towards biomedical applications.[J].Advanced drug delivery reviews,2008(3):299-327. |
| [12] | Chen,A.-Z.;Lin,X.-F.;Wang,S.-B.;Li,L.;Liu,Y.-G.;Ye,L.;Wang,G.-Y. .Biological evaluation of Fe 3O 4-poly(l-lactide)-poly(ethylene glycol)-poly(l-lactide) magnetic microspheres prepared in supercritical CO 2[J].Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research,2012(1):75-82. |
| [13] | 赵趁,陈爱政,王士斌,刘源岗.超临界二氧化碳流体技术制备多孔微球研究进展[J].科学通报,2012(36):3459-3466. |
| [14] | Lee LY;Lim LK;Hua J;Wang CH .Jet breakup and droplet formation in near-critical regime of carbon dioxide-dichloromethane system[J].Chemical Engineering Science,2008(13):3366-3378. |
| [15] | Ozlem Y C;Emel O .In vitro release kinetics of polycaprolactone encapsulated plant extract fabricated by supercritical antisolvent process and solvent evaporation method[J].Journal of Supercritical Fluids,2012,62:219. |
| [16] | Ke Wu;Jing Li .Precipitation of a biodegradable polymer using compressed carbon dioxide as antisolvent[J].The Journal of Supercritical Fluids,2008(2):211-216. |
| [17] | Pratibhash Chattopadhyay;Ram B. Gupta .Supercritical CO_2 Based Production of Magnetically Responsive Micro- and Nanoparticles for Drug Targeting[J].Industrial & Engineering Chemistry Research,2002(24):6049-6058. |
| [18] | Ren J;Teng X;Zhang P .Method for preparing drug-carrying magnetic polymer particle using supercritical CO2 antisolvent process[J].Chemical Engineering Science,2005,24(07):87. |
| [19] | Chen AZ;Kang YQ;Pu XM;Yin GF;Li Y;Hu JY .Development of Fe3O4-poly(L-lactide) magnetic microparticles in supercritical CO2[J].Journal of Colloid and Interface Science,2009(2):317-322. |
| [20] | Li L;Wang S B et al.Study of Fe3O4-PLLA-PEG-PLLA magnetic microspheres based on supercritical CO2:Preparation,physicochemical characterization and drug loading investigation[J].Journal of Supercritical Fluids,2012,67(05):139. |
| [21] | Lam U T;Yoganathan R et al.Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process[J].Australian Journal of Chemistry,2011,57(06):89. |
| [22] | 王丽萍,唐韶坤.应用超临界流体技术制备纳米磁性氧化铁的研究进展[J].化工进展,2011(02):339-344. |
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