以5,5'-偶氮二水杨酸作为起始剂,异佛尔酮二异氰酸酯作为交联剂,合成了新型的葡聚糖水凝胶作为药物靶向载体,并对载体材料进行了红外、溶胀度及扫描电镜的分析研究.水凝胶的溶胀实验结果说明:随着水凝胶交联程度的降低,其溶胀程度增大,平衡时间延长.扫描电镜观察表面形态验证了充分溶胀的水凝胶具有多孔、均相结构,而且孔径随着交联度的增大而减小.该类水凝胶可作为多肽和蛋白类药物的载体.
参考文献
| [1] | Saffran M;Kumar G S;Savariar C .[J].Science,1986,233:1081. |
| [2] | Kumar G S.[A].Lancaster,PA:Technomic Publishing Company,Inc,1992 |
| [3] | Shantha KL.;Rao KP.;Ravichandran P. .AZO POLYMERIC HYDROGELS FOR COLON TARGETED DRUG DELIVERY[J].Biomaterials,1995(17):1313-1318. |
| [4] | Stubbe B;Maris B;Van den Mooter G et al.[J].Journal of Controlled Release,2001,75:103. |
| [5] | Jiri Labsky .[J].BIOMATERIALS,2003,24:4031. |
| [6] | Kimura Y;Kumagai Y;Yamane H et al.[J].POLYMER,1992,33(24):5294. |
| [7] | Yamaoka T.;Sasatani H.;Kim SI.;Kimura Y.;Makita Y. .Linear type azo-containing polyurethane as drug-coating material for colon-specific delivery: its properties, degradation behavior, and utilization for drug formulation[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2000(2/3):187-197. |
| [8] | Samyn C;Kalala W;Mooter G V D et al.[J].International Journal of Pharmaceutics,1995,121:211. |
| [9] | Kurzer F;Douraghi-Zadeh K .[J].Chemical Reviews,1967,67(02):107. |
| [10] | Joo SH.;Jin JI.;Kim DC.;Zin WC.;Yun YK. .Synthesis of liquid crystalline polyesters of various types by acyclic diene metathesis polymerization[J].Macromolecules,2000(18):6704-6712. |
| [11] | Banerjee A;Grewer C;Ramakrishnan L et al.[J].Journal of Organic Chemistry,2003,68(22):8363. |
| [12] | Junying Lai;Li-Qun Wang;Kehua Tu et al.[J].Macromolecular Rapid Communications,2005,26:1572. |
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