采用表面引发原子转移自由基聚合法(SI-ATRP),将磺铵两性离子聚合物(PDMMSA)构建在尼龙膜表面.采用WCA、AFM、ATR-FTIR对改性前后尼龙膜进行表征,结果显示,两性离子聚合物已成功地接枝在尼龙膜表面,改性后尼龙膜的表面润湿性比改性前得到了很好的改善.采用蛋白质吸附、血小板粘附实验评价改性前后尼龙膜抗凝血性能的变化,结果表明,即使改性时间只有20min的尼龙膜都具有优异的抗凝血性能.
参考文献
[1] | 姚婉清.抗凝血性高分子生物材料的表面改性方法研究进展[J].嘉应学院学报,2010(05):53-57. |
[2] | 林思聪.高分子生物材料分子工程研究进展(上[J].高分子通报,1997(01):5. |
[3] | Liu P S;Chen Q;Wu S S et al.Surface modification of cellulose membranes with zwitterionic polymers for resistance to protein adsorption and platelet adhesion[J].Journal of Membrane Science,2010,350(1-2):387. |
[4] | Yuan J;Zhu J;Zhu C H et al.Platelet adhesion on a polyurethane surface grafted with a zwitterionic monomer of sulfobetaine via a Jeffanine spacer[J].Polym lnt,2004,53(11):1722. |
[5] | Jun ZHU,Chang-wang Pan,LING Tong,Han Yan,Jian Shen,Si-cong Lin.IMPROVING NONTHROMBOGENICITY OF CHITIN WITH ZWITTERIONIC STRUCTURE OF SULFOBETAINE[J].高分子科学(英文版),2005(04):449-452. |
[6] | Cardoso J;Manero O .Thermal and dilute-solution properties of zwitterionic copolymers[J].Journal of Polymer Science Part B:Polymer Physics,1991,29(06):639. |
[7] | Lee WF.;Tsai CC. .SYNTHESIS AND SOLUBILITY OF THE POLY(SULFOBETAINE)S AND THE CORRESPONDING CATIONIC POLYMERS .2. AQUEOUS SOLUTION PROPERTIES OF POLY[N,N'-DIMETHYL(ACRYLAMIDO PROPYL) AMMONIUM PROPANE SULFONATE][J].Polymer: The International Journal for the Science and Technology of Polymers,1995(2):357-364. |
[8] | Jin-Shan Wang;Krzysztof Matyjaszewski .Controlled/'Living' Radical Polymerization. Atom Transfer Radical Polymerization in the Presence of Transition-Metal Complexes[J].Journal of the American Chemical Society,1995(20):5614-5615. |
[9] | 倪刚,杨武,何晓燕,薄丽丽,吕维莲.表面引发聚合反应研究进展[J].化学进展,2005(06):1074-1080. |
[10] | F.J.Xu;J.P.Zhao;E.T.Kang .Functionalization of Nylon Membranes via Surface-Initiated Atom-Transfer Radical Polymerization[J].Langmuir: The ACS Journal of Surfaces and Colloids,2007(16):8585-8592. |
[11] | Kainthan RK;Gnanamani M;Ganguli M;Ghosh T;Brooks DE;Maiti S;Kizhakkedathu JN .Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA[J].Biomaterials,2006(31):5377-5390. |
[12] | Higuchi A;Sugiyama K;Yoon BO;Sakurai M;Hara M;Sumita M;Sugawara S;Shirai T .Serum protein adsorption and platelet adhesion on pluronic-adsorbed polysulfone membranes.[J].Biomaterials,2003(19):3235-3245. |
[13] | Zhang Z;Chen SF;Chang Y;Jiang SY .Surface grafted sulfobetaine polymers via atom transfer radical polymerization as superlow fouling coatings[J].The journal of physical chemistry, B. Condensed matter, materials, surfaces, interfaces & biophysical,2006(22):10799-10804. |
[14] | Ping-Sheng Liu;Qiang Chen;Xiang Liu .Grafting of Zwitterion from Cellulose Membranes via ATRP for Improving Blood Compatibility[J].Biomacromolecules,2009(10):2809-2816. |
[15] | 朱吴兰.红外光谱法鉴别不同种类的聚酰胺[J].塑料,2009(03):114-117. |
[16] | Seo JH;Matsuno R;Konno T;Takai M;Ishihara K .Surface tethering of phosphorylcholine groups onto poly(dimethylsiloxane) through swelling-deswelling methods with phospholipids moiety containing ABA-type block copolymers.[J].Biomaterials,2008(10):1367-1376. |
[17] | Lee JH;Ju YM;Kim DM .Platelet adhesion onto segmented polyurethane film surfaces modified by addition and crosslinking of PEO-containing block copolymers.[J].Biomaterials,2000(7):683-691. |
[18] | Roach, P;Farrar, D;Perry, CC .Interpretation of protein adsorption: Surface-induced conformational changes[J].Journal of the American Chemical Society,2005(22):8168-8173. |
[19] | Sigal GB.;Whitesides GM.;Mrksich M. .Effect of surface wettability on the adsorption of proteins and detergents[J].Journal of the American Chemical Society,1998(14):3464-3473. |
[20] | Ishihara K;Nomura H;Mihara T;Kurita K;Iwasaki Y;Nakabayashi N .Why do phospholipid polymers reduce protein adsorption?[J].Journal of biomedical materials research, Part B. Applied biomaterials,1998(2):323-330. |
[21] | Goodmal S L;Grasel T G;Cooper S L et al.Platelet shape change and cytoskeletal reorganization on polyurethaneureas[J].Journal of Biomedical Materials Research,1989,23(01):105. |
上一张
下一张
上一张
下一张
计量
- 下载量()
- 访问量()
文章评分
- 您的评分:
-
10%
-
20%
-
30%
-
40%
-
50%