用光电子能谱(XPS)证明了3 nn~5 nm的氧化铈晶格中含有44%的Ce3+,因而具有较强的还原性;用电子顺磁共振(EPR)证明这种纳米氧化铈具有清除自由基的性质;2009年美国J Colon等的研究团队用体外试验(细胞培养,In Vitro)和无胸腺的裸鼠的体内试验(生命耐久性,In Vivo)证明了在放射线作用下,有3 nm ~5 nmCeO2粒子存在情况下正常细胞和组织受到保护.这些研究结果,对人类的癌症治疗提出了新方案,即纳米氧化铈加合适的放疗,可克服放疗过程正常细胞和组织受损的弊病.3 nm~5 nm的氧化铈因能清除体内自由基而又是一种潜在抗衰老剂.本文作者认为要达到Ⅰ期人体试验的要求还应在安全性、有效性和选择性方面做更多的工作,同时展示了一张由本文作者自己制作的3 nm~5 nm的氧化铈的电镜照片.
参考文献
[1] | R.Perez-Hernandez;F.Aguilar;A.Gomez-Cortes;G.Diaz .NO reduction with CH_4 or CO on Pt/ZrO_2-CeO_2 catalysts[J].Catalysis Today,2005(0):175-180. |
[2] | Tarnuzzer RW;Colon J;Patil S;Seal S .Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage[J].Nano letters,2005(12):2573-2577. |
[3] | Francesca Pagliari;Corrado Mandoli;Giancarlo Forte;Eugenio Magnani;Stefania Pagliari;Giorgia Nardone;Silvia Licoccia;Marilena Minieri;Paolo Di Nardo;Enrico Traversa .Cerium Oxide Nanoparticles Protect Cardiac Progenitor Cells from Oxidative Stress[J].ACS nano,2012(5):3767-3775. |
[4] | Buonocore G;Perrone S;Tataranno ML .Oxygen toxicity: chemistry and biology of reactive oxygen species.[J].Seminars in fetal & neonatal medicine,2010(4):186-190. |
[5] | 谢利霞,王殿华.活性氧与血管内皮细胞的信号转导[J].国外医学(生理、病理科学与临床分册),2004(02):153-155. |
[6] | 徐芝勇.细胞内活性氧与肿瘤[J].生物学通报,2004(09):24-25. |
[7] | Heckert EG;Karakoti AS;Seal S;Self WT .The role of cerium redox state in the SOD mimetic activity of nanoceria.[J].Biomaterials,2008(18):2705-2709. |
[8] | Schubert D;Dargusch R;Raitano J;Chan SW .Cerium and yttrium oxide nanoparticles are neuroprotective[J].Biochemical and Biophysical Research Communications,2006(1):86-91. |
[9] | Das M;Patil S;Bhargava N;Kang JF;Riedel LM;Seal S;Hickman JJ .Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons[J].Biomaterials,2007(10):1918-1925. |
[10] | Tseng,M.T.;Lu,X.;Duan,X.;Hardas,S.S.;Sultana,R.;Wu,P.;Unrine,J.M.;Graham,U.;Butterfield,D.A.;Grulke,E.A.;Yokel,R.A. .Alteration of hepatic structure and oxidative stress induced by intravenous nanoceria[J].Toxicology and Applied Pharmacology,2012(2):173-182. |
[11] | Bumajdad A;Eastoe J;Mathew A .Cerium oxide nanoparticles prepared in self-assembled systems[J].Advances in colloid and interface science,2009(0):56-66. |
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