{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"由磺胺甲(噁)唑、对羟基苯乙酮和芳香醛反应直接合成了13个未见报道的β-氨基酮,反应选择性发生在羰基α位. 产物结构通过1H NMR、13C NMR、MS进行了表征. 生物活性试验显示,低浓度范围,所得化合物不仅对蛋白质酪氨酸磷酸酶1B(PTP1B)和α-葡萄糖苷酶有一定抑制活性,而且对过氧化物酶体增殖物激活受体反应元件(PPRE)具有中等强度的激动活性,8个化合物的激动活性超过40%,其中化合物11的活性达到72.7%.","authors":[{"authorName":"张映霞","id":"cb5560a8-380d-4000-ae2b-ee9139c424da","originalAuthorName":"张映霞"},{"authorName":"晏菊芳","id":"1bbe313e-463e-4552-b3b3-796900dd1096","originalAuthorName":"晏菊芳"},{"authorName":"范莉","id":"caf6bcf0-202f-4833-a844-7ab9920c5cec","originalAuthorName":"范莉"},{"authorName":"张蔚瑜","id":"9bae86a2-9d22-49e0-8aba-4157ca6d9ba9","originalAuthorName":"张蔚瑜"},{"authorName":"苏小燕","id":"107dbad2-1c5a-4ea2-b3c7-4432940df3d1","originalAuthorName":"苏小燕"},{"authorName":"陈欣","id":"c5e4f043-222f-47a0-9793-dd793c71cdba","originalAuthorName":"陈欣"},{"authorName":"唐雪梅","id":"fd1127c4-bd10-45c6-885d-cf969d4090b2","originalAuthorName":"唐雪梅"},{"authorName":"周祖文","id":"4857a675-966c-4a2e-a946-744673fbe821","originalAuthorName":"周祖文"},{"authorName":"杨大成","id":"31515f6d-1f48-414e-88ca-f68185f0cf0e","originalAuthorName":"杨大成"}],"doi":"10.3724/SP.J.1095.2010.90506","fpage":"1026","id":"94226dfd-1b5b-4b30-855a-ba8d72b4c9e3","issue":"9","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"bc51deee-5719-4432-974b-9c3513276127","keyword":"α-葡萄糖苷酶","originalKeyword":"α-葡萄糖苷酶"},{"id":"08eba2e1-6e3a-4653-9154-72409cd25f58","keyword":"蛋白质酪氨酸磷酸酶1B","originalKeyword":"蛋白质酪氨酸磷酸酶1B"},{"id":"9abd9038-7f9c-4c2d-b813-4eca361f83f6","keyword":"过氧化物酶体增殖物激活受体反应元件","originalKeyword":"过氧化物酶体增殖物激活受体反应元件"},{"id":"afc59af6-3648-49ce-b0a2-fa62f69b9d09","keyword":"对羟基苯乙酮","originalKeyword":"对羟基苯乙酮"},{"id":"2d389da7-a548-4a0c-93b0-b909b78e290a","keyword":"磺胺甲(噁)唑","originalKeyword":"磺胺甲(噁)唑"},{"id":"150213cf-adfa-4b7b-9538-39cc58bfe0be","keyword":"β-氨基酮","originalKeyword":"β-氨基酮"},{"id":"3900a608-2ea1-4018-afb3-1d82788bc627","keyword":"Mannich反应","originalKeyword":"Mannich反应"}],"language":"zh","publisherId":"yyhx201009008","title":"4-(3-(4-羟基苯基)-3-氧代-1-芳基丙氨基)-N-(5-甲基异唑-3-基)苯磺酰胺的合成及其抗糖尿病活性","volume":"27","year":"2010"},{"abstractinfo":"在液相状态下,吸热的甲醇水相重整制氢反应和放热的苯乙酮液相加氢反应可使用相同类型的催化剂,并在相近的反应温度和压力条件下进行. 据此,提出利用甲醇水相重整制氢原位还原苯乙酮制备α-苯乙醇,将两个反应偶合形成一种新的苯乙酮加氢还原方法,即苯乙酮液相原位加氢还原法. 通过这种偶合,在Raney Ni催化剂作用下实现了羰基的高选择性还原(α-苯乙醇选择性可达95%), 同时水相重整过程中甲醇的转化率和氢的选择性也得到明显提高. 实验结果表明,反应条件是影响苯乙酮原位加氢反应性能的重要因素;优化反应的温度、压力、苯乙酮浓度和原料配比可以提高甲醇水相重整制氢选择性和羰基加氢选择性.","authors":[{"authorName":"姜莉","id":"b5ea1457-7d1e-4f6d-94e7-4a7547a299f7","originalAuthorName":"姜莉"},{"authorName":"祝一锋","id":"15d1f1f8-8963-48d3-b8f6-bd643daae941","originalAuthorName":"祝一锋"},{"authorName":"项益智","id":"100e5369-5e3d-4833-ac22-466245c9a448","originalAuthorName":"项益智"},{"authorName":"李小年","id":"717ff6ac-1049-43f4-ade7-d6aaffd05745","originalAuthorName":"李小年"}],"doi":"","fpage":"281","id":"92fc4bc5-d8d3-4a61-ab0c-1d4a4a427af1","issue":"3","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报 "},"keywords":[{"id":"2a868893-dcf4-40fe-b983-de33944788a6","keyword":"液相","originalKeyword":"液相"},{"id":"eea0edea-aa2a-4d1b-9544-dc36a8f6559d","keyword":"甲醇","originalKeyword":"甲醇"},{"id":"bc73c972-d13d-47b5-881b-4d98a7b1c62a","keyword":"重整","originalKeyword":"重整"},{"id":"5440620a-3da7-4112-96a4-20cf706b2f1c","keyword":"苯乙酮","originalKeyword":"苯乙酮"},{"id":"be48ddf8-7a64-4323-b688-e3aede673b31","keyword":"加氢","originalKeyword":"加氢"},{"id":"a2271d55-f48d-4250-946f-7c260a5a01a6","keyword":"苯乙醇","originalKeyword":"苯乙醇"},{"id":"47c2f181-e964-487c-8171-67e4e5f049e5","keyword":"偶合","originalKeyword":"偶合"},{"id":"deaf8a50-6e69-4e1c-8703-d151e3f917a9","keyword":"Raney镍","originalKeyword":"Raney镍"}],"language":"zh","publisherId":"cuihuaxb200703019","title":"甲醇水相重整制氢原位还原苯乙酮制备α-苯乙醇","volume":"28","year":"2007"},{"abstractinfo":"采用焙烧还原法制备了镁铝水滑石负载MnO-4催化剂,并将其应用于催化氧气氧化乙苯合成苯乙酮的反应中.考察了催化剂用量、反应温度、反应时间、MnO-4负载量和镁铝比等因素对催化氧化反应的影响及催化剂的重复使用性能.在优化条件下:催化剂用量3 g,乙苯用量45 mL,反应温度120℃,水滑石结构中n(Mg)/n(Al) =5,氧气流量100 mL/min,苯乙酮产率可达57.0％,苯乙酮选择性可达96.3％,催化剂重复使用3次催化活性降低较小.","authors":[{"authorName":"汪一帆","id":"9ab701ff-52cf-4b37-b75d-c3f42b52ea40","originalAuthorName":"汪一帆"},{"authorName":"周维友","id":"ffef4c7e-d989-49bb-b69f-07bf0da86607","originalAuthorName":"周维友"},{"authorName":"方筱","id":"6b494af0-a465-4983-b676-d5920467fe05","originalAuthorName":"方筱"},{"authorName":"陈群","id":"579c7ef6-8568-4f8d-92a7-0b92d797d10c","originalAuthorName":"陈群"}],"doi":"10.3724/SP.J.1095.2012.00444","fpage":"1017","id":"76eb20a2-4d61-4638-920a-55fd1ceedcac","issue":"9","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"0bea612c-7e81-4647-b4d3-9f358b816cb2","keyword":"水滑石","originalKeyword":"水滑石"},{"id":"07e9bded-ea28-4921-a464-530e02e53590","keyword":"乙苯","originalKeyword":"乙苯"},{"id":"50f26366-4072-4807-b3fc-8f595d40c980","keyword":"绿色氧化","originalKeyword":"绿色氧化"},{"id":"1923ea15-f1c7-48db-bcc7-dfcd96533f9c","keyword":"苯乙酮","originalKeyword":"苯乙酮"}],"language":"zh","publisherId":"yyhx201209008","title":"镁铝水滑石负载MnO-4催化氧化乙苯合成苯乙酮","volume":"29","year":"2012"},{"abstractinfo":"以苯乙酮为模型底物,研究了水相体系中酵母细胞催化前手性芳香酮不对称还原生成相应手性醇的反应特性. 实验发现,酵母细胞催化苯乙酮不对称还原的产物以(S)-α-苯乙醇为主,反应的立体选择性很高,(S)-α-苯乙醇的对映体过量值可达99%左右. 在pH为7～8, 酵母细胞用量为0.2 g/ml的条件下能获得较高的产物收率(可达35%左右). 酵母细胞能选择性地氧化(S)-α-苯乙醇,而留下(R)-α-苯乙醇. 在反应体系中加入合适的吸附树脂,可以降低底物和产物对细胞的毒害作用,显著提高反应底物的初始浓度,从而提高产物收率.","authors":[{"authorName":"杨忠华","id":"f1512d90-ee49-4ff4-a5ca-d0c63666c185","originalAuthorName":"杨忠华"},{"authorName":"姚善泾","id":"62eee081-8364-41d0-b3dd-7e7ab2bcd0ab","originalAuthorName":"姚善泾"},{"authorName":"赵珺","id":"ce33c043-8902-4531-a510-3e6730b63f60","originalAuthorName":"赵珺"}],"doi":"","fpage":"895","id":"fab98673-4d30-4b25-b888-db2b7f89af69","issue":"10","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报 "},"keywords":[{"id":"32af5a0b-1911-42f2-ae4c-eb0abb09c7e9","keyword":"生物催化","originalKeyword":"生物催化"},{"id":"b468d1fb-0b51-4797-a72d-a83b3f5e1279","keyword":"酵母细胞","originalKeyword":"酵母细胞"},{"id":"9985a9fe-dc68-4273-a765-cd046e1b3819","keyword":"苯乙酮","originalKeyword":"苯乙酮"},{"id":"18cfd5c4-338b-40f5-bb6a-f3f7027c2f27","keyword":"不对称还原","originalKeyword":"不对称还原"},{"id":"083d6378-1683-4c01-95b6-d9109bdcc049","keyword":"手性醇","originalKeyword":"手性醇"},{"id":"98c07acc-1052-4a35-80e3-914b33ba3b7f","keyword":"苯乙醇","originalKeyword":"苯乙醇"},{"id":"a983c64e-70a6-420a-9e73-afedc26e1db2","keyword":"树脂","originalKeyword":"树脂"},{"id":"bae5ea6f-8288-40b2-a197-334a3f7cdba6","keyword":"吸附","originalKeyword":"吸附"}],"language":"zh","publisherId":"cuihuaxb200510016","title":"活性酵母细胞不对称催化苯乙酮还原及树脂吸附对反应的促进作用","volume":"26","year":"2005"},{"abstractinfo":"在四乙氧基钛催化下,用丰产的天然薄荷醇为手性源与非手性苯乙酮酸乙酯进行酯交换得到含手性基团的苯乙酮酸薄荷醇酯,酯交换产率为68%;在引入手性基团的立体选择性控制下与硝基甲烷缩合,主要得到R-2-羟基-2-苯基-3-硝基丙酸薄荷醇酯,产率为86%,用IR、1H NMR、13C NMR、元素分析等确认了结构. 用高效液相色谱分析了诱导不对称Henry缩合反应效果,其对映体过量e.e.值为52.8%.","authors":[{"authorName":"向纪明","id":"726b5dc1-af22-42eb-bab7-48f96c9c54f7","originalAuthorName":"向纪明"},{"authorName":"冯小金","id":"948f7331-327e-49a2-8de2-701727442afc","originalAuthorName":"冯小金"},{"authorName":"李宝林","id":"1fe0272e-6c33-4996-bfc1-cf184cdf537b","originalAuthorName":"李宝林"}],"doi":"10.3969/j.issn.1000-0518.2009.07.025","fpage":"857","id":"18316698-ce6f-476a-8515-f564428faaa3","issue":"7","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"94cea58b-cade-445c-a2fe-fa21c015251e","keyword":"α-酮酯","originalKeyword":"α-酮酯"},{"id":"23572683-3074-469d-aa0d-a3345c213f23","keyword":"薄荷醇","originalKeyword":"薄荷醇"},{"id":"51d5edae-9d16-4003-bc3d-68e62707d60c","keyword":"酯交换","originalKeyword":"酯交换"},{"id":"69173343-f47f-406f-b0f4-61809536aab9","keyword":"不对称Henry反应","originalKeyword":"不对称Henry反应"},{"id":"8672bac1-9506-4c62-ad6a-c2743df134a3","keyword":"R-羟基-苯基-硝基丙酸薄荷醇酯","originalKeyword":"R-羟基-苯基-硝基丙酸薄荷醇酯"}],"language":"zh","publisherId":"yyhx200907025","title":"苯乙酮酸薄荷醇酯的合成及其不对称Henry反应","volume":"26","year":"2009"},{"abstractinfo":"用1,4'-二羟基二苯乙酮(BHDB)与间苯二酰氯(IPC)合成了具有良好成炭性的BHDB-IPC聚合物,与磷-氮(P-N)膨胀阻燃体系A1Pi/MPP复配,通过熔融共混法制备了无卤阻燃热塑性聚醚酯弹性体(TPEE)材料.研究表明,BHDB-IPC在700℃时残留率可达45.49％,BHDB-IPC与磷-氮膨胀阻燃体系复配,有助于形成连续致密稳定炭层,提高TPEE的热分解残留率,有效抑制熔滴,产生明显的协效阻燃作用.当TPEE/P-N/BHDB-IPC的质量比为85/12/3.0时,其阻燃等级达到UL94 V-0级别,极限氧指数为28.5％.","authors":[{"authorName":"吴唯","id":"9a43ed73-47b1-4a0b-9c0c-d370f7cf2a07","originalAuthorName":"吴唯"},{"authorName":"张禄冲","id":"af4d6c67-bd32-4b97-adf4-f3e3eac21586","originalAuthorName":"张禄冲"},{"authorName":"钟宇华","id":"35d16bef-cb71-4ec8-a4f0-9ea10761fbc9","originalAuthorName":"钟宇华"},{"authorName":"朱送伟","id":"8e758b88-824a-4470-b102-d660e1b7a37a","originalAuthorName":"朱送伟"},{"authorName":"张雪薇","id":"b4c094e8-09e1-494b-9f87-0e2472fa73eb","originalAuthorName":"张雪薇"}],"doi":"10.16865/j.cnki.1000-7555.2016.03.016","fpage":"86","id":"b2fa8f2d-cbd6-4a7d-b953-7ac8957f95b2","issue":"3","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"9100dc7f-3f59-4371-b760-8cc6b5f483fa","keyword":"阻燃","originalKeyword":"阻燃"},{"id":"180ad415-b746-418e-b1ca-b95826cd10b1","keyword":"热塑性聚醚酯弹性体","originalKeyword":"热塑性聚醚酯弹性体"},{"id":"fcdc9df9-9cb9-40d0-88fc-40bdf31ca7bb","keyword":"1,4'-二羟基二苯乙酮","originalKeyword":"1,4'-二羟基二苯乙酮"},{"id":"e989d33e-806b-485c-bb95-8ccc03154295","keyword":"间苯二酰氯","originalKeyword":"间苯二酰氯"},{"id":"e4cc1317-fc39-41f1-8c69-4d99389d8c2d","keyword":"成炭剂","originalKeyword":"成炭剂"}],"language":"zh","publisherId":"gfzclkxygc201603016","title":"二苯乙酮基聚合物对热塑性聚醚酯弹性体阻燃性能的影响","volume":"32","year":"2016"},{"abstractinfo":"合成了一种酰腙类Schiff碱2,4-二羟基苯乙酮缩异烟酰腙(C14H13N3O3,H2L),经元素分析、红外光谱、紫外光谱、荧光光谱和热重分析等技术手段进行了表征.用X射线单晶衍射测定了它的晶体结构,该晶体属单斜晶系,C2/c空间群,晶胞参数a=2.0102(2) nm,b=0.75891(8) nm,c=1.9530 (2) nm,α=90°,β=111.481(12)°,γ=90°,V=2.7725 (5) nm3,Z=4,Dc=1.4292 g/cm3,R1=0.0422,wR2=0.1113,F(000) =1256.同时进行了量子化学计算研究.使用Gaussian09量子化学程序包,在密度泛函理论(DFT)的B3LYP/6-31 G(d)水平,对化合物的分子结构进行全参数优化计算,获得了热力学参数和几何结构参数,对分子的总能量及前线分子轨道、Mulliken电荷分布进行了分析讨论;同时,用TD-DEF方法计算了化合物的电子吸收光谱和荧光发射光谱.","authors":[{"authorName":"魏赞斌","id":"49b7250d-8e75-448a-8322-1ea2d95954fc","originalAuthorName":"魏赞斌"},{"authorName":"王金池","id":"255db830-0aa6-4bb0-9820-cb85f3988e52","originalAuthorName":"王金池"},{"authorName":"江霞","id":"c246517d-0a4b-435f-a6b1-66c37dfcad39","originalAuthorName":"江霞"},{"authorName":"李颖茜","id":"c4002007-dd77-417c-a563-ee8f40a48bcb","originalAuthorName":"李颖茜"},{"authorName":"陈广慧","id":"828a71ff-0f68-4ece-97f6-787e315590c8","originalAuthorName":"陈广慧"},{"authorName":"解庆范","id":"d432b0d8-3540-4fbc-b62c-62c4b450becb","originalAuthorName":"解庆范"}],"doi":"10.11944/j.issn.1000-0518.2015.09.150014","fpage":"1014","id":"dbcedc1c-0e08-430c-a86c-e4538bc19915","issue":"9","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"2a875f14-63fc-48fd-b32c-d0b7b56566f3","keyword":"异烟酰腙","originalKeyword":"异烟酰腙"},{"id":"345c53d9-7486-4d14-8bc6-adb6eea11472","keyword":"晶体结构","originalKeyword":"晶体结构"},{"id":"5dad0c89-e1df-4263-a595-03fafd835b0f","keyword":"量子化学计算","originalKeyword":"量子化学计算"},{"id":"0f5ccdf1-8c60-43cb-969e-7591069c6d26","keyword":"光谱性质","originalKeyword":"光谱性质"},{"id":"f8055d48-7360-4b03-ada4-15b2ebb4e50d","keyword":"热稳定性","originalKeyword":"热稳定性"}],"language":"zh","publisherId":"yyhx201509006","title":"2,4-二羟基苯乙酮缩异烟酰腙的实验和DFT理论研究:合成、晶体结构和性质及量化计算","volume":"32","year":"2015"},{"abstractinfo":"系统研究了对氯苯酚与2,4-二氯苯乙酮间的Ullmann反应,考察了催化剂,反应溶剂,反应物配比,及微波辐射对反应的影响.加入催化剂使反应的邻对位取代反应表现出很好的定位效应.利用GCD检测探讨了反应条件对反应副产物的影响.研究表明,采用氯化亚铜为催化剂,以二甲苯与二甲基甲酰胺为混合溶剂,间二氯苯乙酮过量20%时能以较好的产率合成4-(4-氯苯氧基)-2-氯苯乙酮.微波辐射对Ullmann反应具有促进作用.","authors":[{"authorName":"兰支利","id":"e643f4ad-dee2-4618-a2e0-3e856afc1e23","originalAuthorName":"兰支利"},{"authorName":"吕妍","id":"10b0f0e5-d65b-4e8c-9184-8881f4c1398a","originalAuthorName":"吕妍"},{"authorName":"谢永耀","id":"a4687e41-238a-4749-8775-1f3c2b4f7a1a","originalAuthorName":"谢永耀"},{"authorName":"刘准","id":"fad9790f-332d-4a2b-9bd3-5e50a1261822","originalAuthorName":"刘准"},{"authorName":"谢庆兰","id":"10fbcb73-d441-4f63-9b60-5a1066ceeedf","originalAuthorName":"谢庆兰"}],"doi":"10.3969/j.issn.1000-0518.2002.04.011","fpage":"346","id":"36bd222a-49f3-4681-87fd-ee3746e5e748","issue":"4","journal":{"abbrevTitle":"YYHX","coverImgSrc":"journal/img/cover/YYHX.jpg","id":"73","issnPpub":"1000-0518","publisherId":"YYHX","title":"应用化学"},"keywords":[{"id":"cb9ae23f-90af-4939-be60-327da1261a8d","keyword":"二芳醚","originalKeyword":"二芳醚"},{"id":"ec73ed8d-ff97-42ce-a05e-c682d7eababc","keyword":"催化","originalKeyword":"催化"},{"id":"a0360880-b6f7-47d7-9714-21a739c0a5ef","keyword":"微波辐射","originalKeyword":"微波辐射"},{"id":"c282df57-8973-4ec6-bbd1-cdfcd7ccf19d","keyword":"定位选择性","originalKeyword":"定位选择性"}],"language":"zh","publisherId":"yyhx200204011","title":"4-(4-氯苯氧基)-2-氯苯乙酮的催化合成及微波促进作用","volume":"19","year":"2002"},{"abstractinfo":"研究了在高压CO2条件下利用粗状假丝酵母Candida valida CICC1444活性细胞催化苯乙酮不对称还原合成(R)-α-苯乙醇.高压CO2条件可对粗状假丝酵母细胞的活性产生一定的影响,但反应的选择性反而有所提高,证实了高压CO2作为该反应环境是可行的.考察了底物浓度、细胞用量、反应温度和压力等因素对反应的影响.结果表明,这些因素对反应产率有很大的影响,在最佳反应条件下,反应底物苯乙酮的转化率和产物α-苯乙醇的产率均可达90%以上,对映体过量值(ee)保持在80%左右.与常压静置条件下的反应相比,高压CO2条件下粗状假丝酵母催化苯乙酮不对称还原反应的转化率和产率分别提高了20%和40%左右,对映体选择性也提高了5%～10%.","authors":[{"authorName":"应小姣","id":"72f2d9f0-e459-437d-876f-c63e6cd3c543","originalAuthorName":"应小姣"},{"authorName":"姚善泾","id":"835dee0d-3cfa-4ad1-a03f-61162560430b","originalAuthorName":"姚善泾"},{"authorName":"关怡新","id":"e5d88128-1c4b-40ef-9b3e-0507c3474a8a","originalAuthorName":"关怡新"}],"doi":"","fpage":"631","id":"9ce9fe49-0583-451e-b49b-0772a22e3711","issue":"7","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报 "},"keywords":[{"id":"7412dfff-3286-4d31-b0f1-3bdbcd979ee8","keyword":"高压二氧化碳","originalKeyword":"高压二氧化碳"},{"id":"9b686fee-839e-402a-8585-fdcbb2d1707a","keyword":"粗状假丝酵母","originalKeyword":"粗状假丝酵母"},{"id":"bcb650e2-bbf5-4873-ae0f-7ecce1e42aaf","keyword":"全细胞","originalKeyword":"全细胞"},{"id":"05ab0576-16bf-40af-866c-ecf606a8f40b","keyword":"生物催化","originalKeyword":"生物催化"},{"id":"5142e8e7-ddfb-49a0-a768-75cfdad27132","keyword":"苯乙酮","originalKeyword":"苯乙酮"},{"id":"8e08253a-b75e-428e-996a-f4052e00cb56","keyword":"不对称还原","originalKeyword":"不对称还原"},{"id":"d3283ec0-ce1e-4628-a906-bcf2111086e8","keyword":"α-苯乙醇","originalKeyword":"α-苯乙醇"}],"language":"zh","publisherId":"cuihuaxb200607021","title":"高压CO2条件下粗状假丝酵母催化苯乙酮不对称还原合成α-苯乙醇","volume":"27","year":"2006"},{"abstractinfo":"以苯乙酮作为模型底物,通过制备类球红杆菌(Rhodobacter sphaeroides)的载色体和分离纯化的胞内氧化还原酶混合液,构建了以类球红杆菌全细胞为催化剂、氧化还原酶为催化剂以及载色体与氧化还原酶偶合三种不对称还原反应体系,并通过向反应体系中加入最适氢供体乙酸钠和电子供体硫代硫酸钠提高产物的转化收率.通过检测目标产物的收率、对映体过量(ee)值和光学构型,分析了光控不对称还原的生物催化机理,发现光照可以改变胞内(S)-氧化还原酶和(R)-氧化还原酶的活性,从而产生不同构型的产物,加入电子供体和氢供体后,反应收率和ee值提高的原因是由于分别补充了细菌叶绿素分子Bchl失去的电子和NADPH再生所需的活性氢.","authors":[{"authorName":"王梦亮","id":"50ab0787-3394-4a4d-92a2-de6da3ed15a7","originalAuthorName":"王梦亮"},{"authorName":"胡锐","id":"c574d372-c6cd-4002-a0cc-10ed2c415fe4","originalAuthorName":"胡锐"},{"authorName":"郭学林","id":"d71c39d1-410d-4ef8-a6e5-9350e67a602c","originalAuthorName":"郭学林"},{"authorName":"闫甫昆","id":"7c9a5b47-8e0f-4c17-bf6a-7aa0637a1902","originalAuthorName":"闫甫昆"},{"authorName":"刘滇生","id":"f49cede3-f2b1-4726-a2fd-5408c9cf8ff1","originalAuthorName":"刘滇生"}],"doi":"","fpage":"233","id":"7b605022-ebbe-4b06-9083-797a3b1191fd","issue":"3","journal":{"abbrevTitle":"CHXB","coverImgSrc":"journal/img/cover/CHXB.jpg","id":"18","issnPpub":"0253-9837","publisherId":"CHXB","title":"催化学报 "},"keywords":[{"id":"af4420a2-11d6-45e6-bddc-83662f0569fb","keyword":"类球红杆菌","originalKeyword":"类球红杆菌"},{"id":"b986b14d-790a-4012-bf3f-a359ae73dff9","keyword":"氧化还原酶","originalKeyword":"氧化还原酶"},{"id":"9eb5e4b6-dbe7-416b-a656-dbf2e7f6a954","keyword":"光控不对称还原","originalKeyword":"光控不对称还原"},{"id":"3f4accf9-8902-49e3-a722-4fb16b7d01a1","keyword":"苯乙酮","originalKeyword":"苯乙酮"},{"id":"adeec5fc-2d56-4a4b-8457-a20651367f89","keyword":"苯乙醇","originalKeyword":"苯乙醇"},{"id":"9ee95109-3c00-498a-834e-ae50507291f6","keyword":"载色体","originalKeyword":"载色体"}],"language":"zh","publisherId":"cuihuaxb200803008","title":"光控光合菌生物催化苯乙酮不对称还原的反应机理","volume":"29","year":"2008"}],"totalpage":14098,"totalrecord":140972}