Tan Guoxin
,
Ouyang Kongyou
,
Wang Hang
,
Zhou Lei
,
Wang Xiaolan
,
Liu Yan
,
Zhang Lan
,
Ning Chengyun
材料科学技术（英文）
doi:10.1016/j.jmst.2016.07.012
The objective of this study was to determine the role of functional groups of silane coupling on bioactive titanium (Ti) surface by electrochemical deposition, and calcium phosphate (CaP) coating, as well as bone cell adhesion and proliferation. Methyl group (—CH3), amino group (—NH2), and epoxy group (—glyph name—C(O)C) were introduced onto the bioactive Ti surface using self-assembled monolayers (SAMs) with different silane coupling agents as molecular bridges. The effect of the surface functional groups on the growth features of the CaP crystals was analyzed (including chemical compositions, element content, minerals morphology and crystal structure etc.). CH3-terminated SAMs showed a hydrophobic surface and others were hydrophilic by contact angle measurement; NH2-terminated SAMs showed a positive charge and others were negatively charged using zeta-potential measurement. Scanning electron microscopy results confirmed that flower-like structure coatings consisting of various pinpoint-like crystals were formatted by different functional groups of silane coupling, and the CaP coatings were multicrystalline consisting of hydroxyapatite (HA) and precursors. CaP coating of CH3-terminated SAMs exhibited more excellent crystallization property as compared to coatings of —NH2 and —C(O)C groups. In vitro MC3T3-E1 cells adhesion and proliferation were performed. The results showed that CaP coatings on silane coupling functionalized surfaces supported cell adhesion and proliferation. Thus, these functional groups of silane coupling on Ti can form homogeneous and oriented nano-CaP coatings and provide a more biocompatible surface for bone regeneration and biomedical applications.
关键词:
Silane coupling
,
Molecular bridge
,
Calcium phosphate coatings
,
Titanium
,
Electrochemical deposition
Zhou Zhengnan
,
Li Weiping
,
He Tianrui
,
Yu Peng
,
Tan Guoxin
,
Ning Chengyun
材料科学技术（英文）
doi:10.1016/j.jmst.2016.06.023
In this research, polypyrrole nanocone arrays doped with β-Naphthalene sulphonic acid (PPy-NSA) were built. This film was expected to control protein adsorption and bacterial adhesion by potential-induced reversibly redox. The scanning Kelvin probe microscopy (SKPM) and surface contact angles (SCA) tests suggested that the surface potential and wettability of PPy-NSA nanocone arrays could be controlled by simply controlling its redox property via applying potential. The controllable surface potential and wettability in return controlled the adsorption of protein and adhesion of bacteria. The proposed material might find application in the preparation of smart biomaterial surfaces that can regulate proteins and bacterial adhesion by a simple potential switching.
关键词:
Polypyrrole
,
Protein adsorption
,
Bacterial adhesion
,
Nanocone arrays
,
Control
