Jin Shujing
,
Ren Ling
,
Yang Ke
材料科学技术（英文）
doi:10.1016/j.jmst.2016.06.022
Although being an essential trace element required for human body health, Cu has long been seriously considered toxic when its amount exceeds certain limitation, which significantly limited the wide application of Cu in biomaterials. However, more and more bio-functions and benefits of Cu were found and confirmed, attracting the attention from biomaterials researchers in recent years. People have tried to immobilize Cu into biomaterials by various ways, in order to develop novel bio-functional Cu containing biomaterials with better bio-adaptions, and several different bio-functions of them have been demonstrated. This paper makes a review of the development of novel bio-functional Cu containing biomaterials, and focuses on their unique roles in enhancing bio-adaption of biomedical materials, including antibacterial performance, stimulating angiogenesis, promoting osteogenesis and inhibition of in-stent restenosis, aiming at proposing a prospective development direction for biomedical materials with better bio-adaptions.
关键词:
Biomaterials
,
Cu
,
Antibacterial
,
Angiogenesis
,
Osteogenesis
,
In-stent restenosis
Honglian DAI
,
Shipu LI
,
Yuhua YAN
,
Xianying CAO
,
Xuehui LU
,
Yang LENG
材料科学技术（英文）
To study the osteogenesis and transformation process of calcium phosphate bioceramic in vivo, biodegradable porous beta-tricalcium phosphate ceramics (β-TCP, 5×8 mm) were implanted in the tibia of rabbits. β-TCP ceramics with surrounding bone tissue were retrieved and observed by SEM, TEM and EPMA every month after implantation. The results showed that osteogenesis was active and β-TCP ceramics bonded to bones directly. The new bones were forming and maturing as materials were continuously degrading, and materials were finally replaced by new bone. Parts of the materials were degraded, absorbed and recrystallized, while the rest were dispersed to the spongy bone and the Haversian lamella in an irregular arrangement, becoming incorporated into bone formation directly by remodeling the structure. Some β-TCP crystals cleaved along its (001) rhombohedral plane and formed lath-like crystals in vivo.
关键词:
Calcium phosphate ceramics
,
null
,
null
,
null
,
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